Buy NOTEXIN from Notechis scutatus

$190.00$2,700.00

Name NOTEXIN 
Molecular formula Np Fraction: C591H878N164O175S16
Ns Fraction: C591H878N166O175S16
Description It is a toxic presynaptic phospholipase A2 (PLA2) with potent myotoxic activity.

Contains:

– Notexin Np (~60%)
– Notechis Ns (33%), a minor natural variant with K replaced by R in 16


119-amino acid protein with 7 disulfite bonds , from Notechis scutatus snake venom.

Biological activity Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities.
Clear
SKU: N/A Category:

Description

  • Buy NOTEXIN from Notechis scutatus

    Basic phospholipase A2 notexin; Notexine; Notexin Np ; Notexin Ns

    Main features :

    Notexin is a mixture of 2 119-AA peptides structurally and functionally very similar, extracted from the venom of the Tiger Snake Notechis scutatusNotexin Np (~60%) and Notexin Ns (33%), a minor natural variant with K replaced by R in 16.

    Primary structures: Buy NOTEXIN from Notechis scutatusNp: NLVQFSYLIQ CANHGKRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ

    Ns: NLVQFSYLIQ CANHGRRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ

    Disulfide bridges for both peptides: 11-71, 27-118, 29-45, 44-99, 51-92, 60-85, 78-90

    Molecular weight : 13,574 Da

    Buy NOTEXIN from Notechis scutatus Purity: 93%

    Biological activity :

    Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities
    Notexin is directly toxic to skeletal muscle (dystrophic effect) upon local application in vivo.
    Notexin has also direct nephrotoxicity in experimental mice.
    Notexin catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
    Buy NOTEXIN from Notechis scutatus

Identification:

  1. PRODUCT ID : L8104-NOTEXIN
  2. CAS Number : 37223-96-4
  3. UNIPROT ID : P00608 and P00609
  4. PubChem CID :
  5. EC Number: None
  6. InChI Key :
  7. RTECS Number: RD3800000
Product name NOTEXIN  Physical form
CAS No. 37223-96-4 Melting point
RTECS RD3800000 Solubility Well in water and saline
UNIPROT P00608;P00609 Optical Activity
PubChem SID 134222164
PubChem CID
Purity > 93 % (HPLC)
Toxicity(LD50) IVN-MUS LD50: 25 µg/kg
Chemical Name
Storage & Reconstitution
Recommandations
Stable in freeze-dried state.
In solution, keep at -20 °C.
Savety Recommendations For research use only — not intended for food, diagnostic or therapeutic use
Buy NOTEXIN from Notechis scutatus For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Reviews

There are no reviews yet.

Be the first to review “Buy NOTEXIN from Notechis scutatus”

Your email address will not be published. Required fields are marked *