Tetrodotoxin is a highly specific Na⁺ channel blocker in excitable tissues, purified from organs of fish of the Tetraodon genus (Takifugu oblongus).

Molecular formula: C₁₁H₁₇N₃O₈
Chemical structure: Click on the picture on the left.
Molecular weight: 319.27 Da
Purity: ≥ 98%

Biological Activity: Buy TETRODOTOXIN from Fugu fish Tetrodotoxin is a Na+ channels blocker.

Tetrodotoxin (TTX) binds reversibly to site 1 of the fast voltage-gated sodium channel located at the extracellular pore opening of the ion channel. The binding of a molecule to this site temporarily disables the ion channel.
TTX is used as a chemical tool in channel characterization and in fundamental studies of channel function.
TTX is a valuable agent for the silencing of neural activity within a cell culture.

KD (cardiac myocytes in rats): 0.8 nM.
10^-8 M block nervous system; 10^-5 M block heart muscle.
ED₅₀ = 3.7 nM.

Identification: Buy TETRODOTOXIN from Fugu fish

1. PRODUCT ID: L8503-TETRODOTOXIN (Citrate free)
2. CAS Number : 4368-28-9
3. T3DB :T3D2484
4. PubChem CID: 16759596
5. EC Number: 224-458-8
6. InChI Key: CFMYXEVWODSLAX-HUILCFQTSA-N
7. RTECS Number: IO1450000