BUY BATRACHOTOXIN from Phyllobates terribilis Main Features :
BATRACHOTOXIN from Phyllobates terribilis The strongest sodium channel activator so far. Batrachotoxin is an alkaloid purified from skin extract of the poison dart frog Phyllobates terribilis.
High chem is the world exclusive source of this toxin.
Molecular formula: C31H42N2O6
Chemical structure: Click on the picture on the left.
Molecular weight : 538.67 Da
Purity : > 90%
Biological Activity :
Batrachotoxin is a Na+ channels activator.
Batrachotoxin (BTX) is the most active alkaloid binding at receptor site-2 on sodium channels.
BTX activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation.
BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.BTX binding induces many allosteric effects on other channel regions and increases the binding of scorpion alpha-toxins to receptor site-3, of brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Batrachotoxin-sensitive sodium channels are expressed in central and peripheral neurons and in both striated and cardiac muscle, where they regulate excitability.
BTX is used for the study of the function of sodium channels.
BTX is used for the study of the effects of other toxins and of different kinds of drugs (anesthetics, analgesics, antiarrhythmics, anticonvulsants, and antidepressants). Recommended doses: < 1 µg/kg.
Recommended concentrations:0.01 to 10 µmol.
|Product name||BATRACHOTOXIN||Physical form||Film|
|CAS No.||23509-16-2||Melting point|
|RTECS||CR3990000||Solubility||In ethanol, methanol and DMSO|
|UNIPROT||Optical Activity||[alpha]D29 300 – 260° (c = 0.23 in methanol)|
|Purity||> 90 % (HPLC, TLC, Toxicity)|
|Toxicity(LD50)||IPR-MUS LD50: 2 μg/kg|
|Storage & Reconstitution
|Stable at room temperature, store preferably at 4°C
|Savety Recommandations||For research use only — not intended for food, diagnostic or therapeutic use|
BATRACHOTOXIN from Phyllobates terribilis
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.